ASDAS-CRP (Ankylosing Spondylitis Disease Activity Score)
Assess disease activity in Ankylosing Spondylitis.
Ask "How would you describe the overall level of AS neck, back or hip pain you have had?"
Ask "How long does your morning stiffness last from the time you wake up?"
Ask "How would you describe the overall level of pain/swelling in joints other than neck, back or hips you have had?"
The Ankylosing Spondylitis Disease Activity Score (ASDAS) is an index to assess disease activity in Ankylosing Spondylitis (AS).
The prefered score uses CRP, rather than ESR.
ASDAS-CRP = 0.12 x Back Pain + 0.06 x Duration of Morning Stiffness + 0.11 x Patient Global + 0.07 x Peripheral Pain/Swelling + 0.58 x Ln(CRP+1)
ASDAS-ESR = 0.08 x Back Pain + 0.07 x Duration of Morning Stiffness + 0.11 x Patient Global + 0.09 x Peripheral Pain/Swelling + 0.29 x √(ESR)
Back pain, patient global assessment, duration of morning stiffness and peripheral pain/swelling are all assessed on a numerical rating scale (from 0 to 10).
The 3 cut-offs selected to separate these states (figure 1) were: <1.3 between "inactive disease" and "moderate disease activity", <2.1 between "moderate disease activity" and "high disease activity", and >3.5 between "high disease activity" and "very high disease activity".
Cut-offs for improvement scores were: a change ≥1.1 units for "clinically important improvement" and a change ≥2.0 units for "major improvement".
- [1]Lukas C, Landewé R, Sieper J, Dougados M, Davis J, Braun J, van der Linden S, van der Heijde D.: Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis.Annals of the Rheumatic Diseases 2009, 68 (1): 18-24
- [2]van der Heijde D, Lie E, Kvien TK, Sieper J, van den Bosch F, Listing J, Braun J, Landewé R.: ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis.Annals of the Rheumatic Diseases 2009, 68 (12): 1811-8
- [3]Machado P, Landewé R, Lie E, Kvien TK, Braun J, Baker D, van der Heijde D.: Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores.Annals of the Rheumatic Diseases 2011, 70 (1): 47-53
- [4]Machado P, Landewé R, van der Heijde D.: Endorsement of the definitions of disease activity states and improvement scores for the Ankylosing Spondylitis Disease Activity Score (ASDAS): results from the Outcome Measures in Rheumatology (OMERACT) 10 conference.Journal of Rheumatology 2011, 38 (7): 1502-6
Results
Real-time automated computation
The Ankylosing Spondylitis Disease Activity Score (ASDAS) is an index to assess disease activity in Ankylosing Spondylitis (AS).
The prefered score uses CRP, rather than ESR.
ASDAS-CRP = 0.12 x Back Pain + 0.06 x Duration of Morning Stiffness + 0.11 x Patient Global + 0.07 x Peripheral Pain/Swelling + 0.58 x Ln(CRP+1)
ASDAS-ESR = 0.08 x Back Pain + 0.07 x Duration of Morning Stiffness + 0.11 x Patient Global + 0.09 x Peripheral Pain/Swelling + 0.29 x √(ESR)
Back pain, patient global assessment, duration of morning stiffness and peripheral pain/swelling are all assessed on a numerical rating scale (from 0 to 10).
The 3 cut-offs selected to separate these states (figure 1) were: <1.3 between "inactive disease" and "moderate disease activity", <2.1 between "moderate disease activity" and "high disease activity", and >3.5 between "high disease activity" and "very high disease activity".
Cut-offs for improvement scores were: a change ≥1.1 units for "clinically important improvement" and a change ≥2.0 units for "major improvement".
- [1]Lukas C, Landewé R, Sieper J, Dougados M, Davis J, Braun J, van der Linden S, van der Heijde D.: Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis.Annals of the Rheumatic Diseases 2009, 68 (1): 18-24
- [2]van der Heijde D, Lie E, Kvien TK, Sieper J, van den Bosch F, Listing J, Braun J, Landewé R.: ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis.Annals of the Rheumatic Diseases 2009, 68 (12): 1811-8
- [3]Machado P, Landewé R, Lie E, Kvien TK, Braun J, Baker D, van der Heijde D.: Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores.Annals of the Rheumatic Diseases 2011, 70 (1): 47-53
- [4]Machado P, Landewé R, van der Heijde D.: Endorsement of the definitions of disease activity states and improvement scores for the Ankylosing Spondylitis Disease Activity Score (ASDAS): results from the Outcome Measures in Rheumatology (OMERACT) 10 conference.Journal of Rheumatology 2011, 38 (7): 1502-6