Crohn's Disease Activity Index (CDAI)
Assess disease activity in Crohn's disease
Used to calculate % deviation from baseline weight.
Used to calculate % deviation from baseline weight.
The Crohn's Disease Activity Index (CDAI) is utilized in clinical trials to assess disease activity in Crohn's.
CDAI scores can range from 0 to ~600.
A cut-off value of <150 was selected so that most patients below this threshold would be rated by physicians as 'very well'.
The delineator between active and very severe disease was defined as a cut-off value of 450 points.
CDAI scores of 150–219 has been labelled as mildly active disease and scores of 220–450 as moderately active disease.
CDAI has some limitations, which include:
- interobserver variability
- ratings of 'general well being' and 'intensity of abdominal pain' are subjective
- stool frequency is based on a diary filled in by the patient for 7 days before evaluation which doesn't generally get done in routine clinical practice
- it is not accurate in patients with fistulizing and stenosing disease
- it is not useful in patients with previous extensive ileo-colonic resections or stoma
- [1]Best WR.: Predicting the Crohn's disease activity index from the Harvey-Bradshaw Index.nflammatory Bowel Diseases 2006, 12 (4): 304-10
- [2]Best WR, Becktel JM, Singleton JW, Kern F Jr.: Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.Gastroenterology 1976, 70 (3): 439-44
Results
Real-time automated computation
The Crohn's Disease Activity Index (CDAI) is utilized in clinical trials to assess disease activity in Crohn's.
CDAI scores can range from 0 to ~600.
A cut-off value of <150 was selected so that most patients below this threshold would be rated by physicians as 'very well'.
The delineator between active and very severe disease was defined as a cut-off value of 450 points.
CDAI scores of 150–219 has been labelled as mildly active disease and scores of 220–450 as moderately active disease.
CDAI has some limitations, which include:
- interobserver variability
- ratings of 'general well being' and 'intensity of abdominal pain' are subjective
- stool frequency is based on a diary filled in by the patient for 7 days before evaluation which doesn't generally get done in routine clinical practice
- it is not accurate in patients with fistulizing and stenosing disease
- it is not useful in patients with previous extensive ileo-colonic resections or stoma
- [1]Best WR.: Predicting the Crohn's disease activity index from the Harvey-Bradshaw Index.nflammatory Bowel Diseases 2006, 12 (4): 304-10
- [2]Best WR, Becktel JM, Singleton JW, Kern F Jr.: Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.Gastroenterology 1976, 70 (3): 439-44