DAS28-ESR for Rheumatoid Arthritis
Assess disease activity in rheumatoid arthritis.
28 joints are assessed, including: <br /> <br /> Shoulders, Elbows, Knees <br /> In the hands: first through fifth metacarpophalangeal joint, the interphalangeal joint of the thumb, and the second through fifth proximal interphalangeal joint.
28 joints are assessed, including: <br /> <br /> Shoulders, Elbows, Knees <br /> In the hands: first through fifth metacarpophalangeal joint, the interphalangeal joint of the thumb, and the second through fifth proximal interphalangeal joint.
The GH or Global Health parameter represents the patient's self assessment of disease activity on a 0-100 scale where 100 means maximal disease activity.
The development of the DAS (Disease Activity Score) was important because it provided a global summative and continuous score for disease activity assessment.
The original DAS was modified into the DAS28, and is felt to be considerably more practical. The DAS28 eliminated the grading of joints and reduced the number of joints evaluated to 28. It has largely replaced the traditional DAS in clinical trials and in practice.
Evaluation of response to a treatment can be made much easier and more objective using the DAS28. The DAS provides a score between 0 and 10, a larger number indicating more active disease.
When using the score to assess response to treatment, a DAS-28 reduction by 0.6 represents a moderate improvement, while a reduction more than 1.2 represents a major improvement.
Score interpretation
- <2.6 suggests disease remission.
- 2.6-3.2 suggests low disease activity
- >3.2-5.1 suggests moderate disease activity
- >5.1 suggest high disease activity
It should be noted that almost 15% of patients with DAS28 scores of 2.6 (the cut-point for remission) continue to have at least two swollen joints; some may have more than 10 swollen joints yet still be categorized as in "remission" using this composite index.
- [1]Aletaha D, Ward MM, Machold KP et. al.: Remission and active disease in rheumatoid arthritis: defining criteria for disease activity states.Arthritis and Rheumatism 2005, 52 (9): 2625-36
- [2]van der Heijde DM, van 't Hof M, van Riel PL, van de Putte LB.: Development of a disease activity score based on judgment in clinical practice by rheumatologists.Journal of Rheumatology 1993, 20 (3): 579-81
- [3]Prevoo ML, van 't Hof MA, Kuper HH, et. al.: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis.Arthritis and Rheumatism 1995, 38 (1): 44-8
- [4]Saag KG, Teng GG, Patkar NM, et. al.: American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis.Arthritis and Rheumatism 2008 June 15, 59 (6): 762-84
Results
Real-time automated computation
The development of the DAS (Disease Activity Score) was important because it provided a global summative and continuous score for disease activity assessment.
The original DAS was modified into the DAS28, and is felt to be considerably more practical. The DAS28 eliminated the grading of joints and reduced the number of joints evaluated to 28. It has largely replaced the traditional DAS in clinical trials and in practice.
Evaluation of response to a treatment can be made much easier and more objective using the DAS28. The DAS provides a score between 0 and 10, a larger number indicating more active disease.
When using the score to assess response to treatment, a DAS-28 reduction by 0.6 represents a moderate improvement, while a reduction more than 1.2 represents a major improvement.
Score interpretation
- <2.6 suggests disease remission.
- 2.6-3.2 suggests low disease activity
- >3.2-5.1 suggests moderate disease activity
- >5.1 suggest high disease activity
It should be noted that almost 15% of patients with DAS28 scores of 2.6 (the cut-point for remission) continue to have at least two swollen joints; some may have more than 10 swollen joints yet still be categorized as in "remission" using this composite index.
- [1]Aletaha D, Ward MM, Machold KP et. al.: Remission and active disease in rheumatoid arthritis: defining criteria for disease activity states.Arthritis and Rheumatism 2005, 52 (9): 2625-36
- [2]van der Heijde DM, van 't Hof M, van Riel PL, van de Putte LB.: Development of a disease activity score based on judgment in clinical practice by rheumatologists.Journal of Rheumatology 1993, 20 (3): 579-81
- [3]Prevoo ML, van 't Hof MA, Kuper HH, et. al.: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis.Arthritis and Rheumatism 1995, 38 (1): 44-8
- [4]Saag KG, Teng GG, Patkar NM, et. al.: American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis.Arthritis and Rheumatism 2008 June 15, 59 (6): 762-84