Dialysis Duration Needed for Ethylene Glycol Ingestion
Estimate dialysis duration required for ethylene glycol poisoning
Sample dialyzer clearance values: <br><br> Qb (mL/min) 200 300 400 400<br> Qd (mL/min) 500 500 500 800<br> <br><br> Optiflux F160NR: 194 266 308 344<br> Optiflux F180NR: 196 274 323 358<br> Optiflux F200NR: 197 277 330 364<br> Optiflux F250NR: 198 286 344 382<br> <br><br> Qb (mL/min) 200 300 400 500<br> Qd (mL/min) 500 500 500 500<br> <br><br> Exeltra 150: 193 262 305 332<br> Exeltra 170: 196 268 310 341<br> Exeltra 190: 197 273 323 354<br> Exeltra Plus 210: 199 287 350 384<br>
In a toxic alcohol ingestion with ethylene glycol or methanol, dialysis is often required.
The duration of hemodialysis in hours required to achieve a toxin concentration of ≤5 mmol/L can be estimated using the formula [-V ln(5/A)]/0.06k, where V is total body water in liters, A is the initial alcohol concentration in mmol/L, and k is 80 percent of the dialyzer urea clearance in mL/min at the observed blood flow rate.
- [1]Hirsch DJ, Jindal KK, Wong P, Fraser AD.: A simple method to estimate the required dialysis time for cases of alcohol poisoning.Kidney International 2001, 60 (5): 2021-4
- [2]Youssef GM, Hirsch DJ.: Validation of a method to predict required dialysis time for cases of methanol and ethylene glycol poisoning.Youssef GM, Hirsch DJ
- [3]McMurray M, Carty D, Toffelmire EB.: Predicting methanol clearance during hemodialysis when direct measurement is not available.CANNT Journal 2002, 12 (1): 29-38; quiz 32-3
- [4]Burns AB, Bailie GR, Eisele G, McGoldrick D, Swift T, Rosano TG.: Use of pharmacokinetics to determine the duration of dialysis in management of methanol poisoning.American Journal of Emergency Medicine 1998, 16 (5): 538-40
Results
Real-time automated computation
In a toxic alcohol ingestion with ethylene glycol or methanol, dialysis is often required.
The duration of hemodialysis in hours required to achieve a toxin concentration of ≤5 mmol/L can be estimated using the formula [-V ln(5/A)]/0.06k, where V is total body water in liters, A is the initial alcohol concentration in mmol/L, and k is 80 percent of the dialyzer urea clearance in mL/min at the observed blood flow rate.
- [1]Hirsch DJ, Jindal KK, Wong P, Fraser AD.: A simple method to estimate the required dialysis time for cases of alcohol poisoning.Kidney International 2001, 60 (5): 2021-4
- [2]Youssef GM, Hirsch DJ.: Validation of a method to predict required dialysis time for cases of methanol and ethylene glycol poisoning.Youssef GM, Hirsch DJ
- [3]McMurray M, Carty D, Toffelmire EB.: Predicting methanol clearance during hemodialysis when direct measurement is not available.CANNT Journal 2002, 12 (1): 29-38; quiz 32-3
- [4]Burns AB, Bailie GR, Eisele G, McGoldrick D, Swift T, Rosano TG.: Use of pharmacokinetics to determine the duration of dialysis in management of methanol poisoning.American Journal of Emergency Medicine 1998, 16 (5): 538-40