Elevated serum creatinine or hyperkalemia after ACEi/ARB
Estimate risk of elevated serum creatinine or hyperkalemia after ACEi or ARB initiation
Author / Source: Pavel Roshanov, MD MSc
Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) can increase the risk of kidney dysfunction and hyperkalemia. This calculator estimates the short-term risk of an increase in serum potassium to >5.5 mmol/L, a 30% increase in serum creatinine, or both within 30 days of ACEi or ARB initiation.
This equation was derived in two retrospective, population-based cohorts of adults in North America.
- [1]Parikh RV, Nash DM, et. al. : Kidney function and potassium monitoring after initiation of renin-angiotensin-aldosterone system blockade therapy and outcomes in two North American populations.Cardiovascular Quality and Outcomes. 2020.
Results
Real-time automated computation
Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) can increase the risk of kidney dysfunction and hyperkalemia. This calculator estimates the short-term risk of an increase in serum potassium to >5.5 mmol/L, a 30% increase in serum creatinine, or both within 30 days of ACEi or ARB initiation.
This equation was derived in two retrospective, population-based cohorts of adults in North America.
- [1]Parikh RV, Nash DM, et. al. : Kidney function and potassium monitoring after initiation of renin-angiotensin-aldosterone system blockade therapy and outcomes in two North American populations.Cardiovascular Quality and Outcomes. 2020.