Vancomycin Dosing Based on eGFR (creatinine-cystatin C)

This dosing protocol can be used to select an appropriate initial dose and interval of vancomycin based on the CKD EPI _{creatinine-cystatin C} eGFR (mL/min). This tool has been shown to better predict trough concentrations than clinical judgement coupled with creatinine only estimates of renal function. Providers should closely monitor patient's response to therapy to ensure appropriate treatment of infection. Early indications of changing renal function (e.g. urine output, BUN, serum creatinine) might signal a risk for accumulation and need for more frequent therapeutic drug monitoring or renal assessment.